夏雪山


      夏雪山,男,博士,教授,博士研究生导师,澳洲5·(中国)集团有限公司,校长。国家重点研发计划首席科学家,享受国务院特殊津贴,云南省 “兴滇英才支持计划”云岭学者,云南省有突出贡献优秀专业技术人才,云南省中青年学术和技术带头人,云南省传染病流行病学与分子诊断创新团队负责人,云南省分子医学研究中心、云南省分子诊断工程技术研究中心、云南省感染性疾病基因检测工程研究中心负责人、云南省公共卫生与生物安全重点实验室主任。云南省免疫学会、云南省微生物学会副理事长。系统开展云南及周边地区主要流行传染性疾病分子流行病学研究,阐明了主要传染病病原体在不同地域、不同人群中感染特性和基因型、亚型、重组型的分布规律和病原体进化、起源特点,科学分析其流行特性的成因并预测了其对我国疾病流行的影响。开展病毒跨种传播规律研究和新病毒发现与鉴定,首次解析云南省致死性H5N6、H7N9病毒基因组结构,发现并命名多个HIV-1、肝炎病毒新基因型、亚型,提出了多种病毒分类新观点。建立了HCV、KSHV感染树鼩模型和寨卡、基孔肯亚树鼩疾病模型,探索病毒性疾病树鼩模型发病机理。建立了具有云南地方特色的传染病样本库及诊断产品研发技术平台,开发的感染性疾病分子检测系列技术已成果转化、实现产业化。主持国家自然科学基金委NSFC-YN联合基金重点项目、中国中医科学院中医药防治流感技术体系项目、云南省重大科技专项等项目。发表论文300余篇,其中SCI文章182篇;出版专著3部;授权发明专利15项。获云南省科技进步奖一等奖、云南省自然科学奖二等奖等省部奖励5项。
1、联系方式
研究方向:分子病毒学
电话:0871-65922555
邮箱:oliverxia2000@aliyun.com
通讯地址:昆明市呈贡区雨花街道春融西路1168号
2、教育经历
1992.09-1996.07  山东农业大学资源环境学院植物营养专业获农学学士学位
1996.09-1999.07  华中农业大学畜牧兽医学院预防兽医学专业获农学硕士学位
1999.09-2002.12 中国科学院昆明动物研究所分子病毒学与细胞免疫学专业  获理学博士学位
3、工作经历
2003.04-2006.12  昆明理工大学生物与化学工程学院生物工程系系主任        
2006.01-2007.08  日本国立感染症研究所访问学者
2007.01-2010.10  昆明理工大学科技处副处长
2008.07-2008.11  美国犹他大学医学院访问学者
2010.09-2019.04  昆明理工大学生命科学与技术学院院长
2019.05-2022.09  昆明理工大学副校长
2022年-至今      澳洲5·(中国)集团有限公司,校长
4、承担的主要项目
4.1国家重点研发计划项目、支撑计划项目
1)   国家重点研发计划项目:入境人群重大传染病快速排查关键技术研究与应用示范,2023YFC2307400,1500万元,2023.12-2026.11
2)   国家支撑计划项目:实验用树鼩的标准化研究和人类重大疾病树鼩模型创建与集成应用示范课,课题三:3种病毒感染树鼩模型创建的关键技术研究,2014BAI01B01-03,200万,2014.07-2017.06。
4.2国家自然科学基金项目
3)   西南地区快速流行基因型- - 6型HCV病毒培养体系构建及其感染与增殖特性研究,地区基金81260248,49万,2013.01 - 2016.12;
4)   云南边境口岸艾滋病病毒跨境传播特性与演化规律研究,地区基金81460509,55万,2015.01 - 2018.12;
5)   云南驯养野生动物中新型冠状病毒(2019-nCoV)溯源调查与验证,应急专项82041005,150万,2020.03 - 2022.03。
4.3云南南省项目
6)   重点新产品研发计划项目:冠状病毒细胞与动物模型建立及中药药效评价,202003AC100006,100万,2020.02-2021.02;
7)   应用基础研究重点项目:丙型肝炎抗病毒药物疗效影响因素与相关机制研究,2019FA005,50万元,2019.01- 2022.12;
8)   基础研究重点项目:云南及周边地区媒介节肢动物携带病原体调查研究,202101AS070028,50万元,2021.04-2024.03;
9)   重大研究计划项目:云南省主要跨境传入传染病检测鉴定诊断产品开发,2019ZF004,1090万元,2019.01-2021.12;
10) 重点研发计划(社会发展专项):云南省野生动物病原传播风险评价与监测技术体系研究与应用,202103AQ100001,2000万元,2021.07-2024.06;
11) 平台项目:云南省公共卫生与生物安全重点实验室,202402AN360004,200万,2024.01-2025.12;
12) 国际合作项目:云南省胃癌发生关键分子发现与检测技术国际联合实验室,202303AP140017,300万元,2023.01-2025.12。
5、代表论文
1)      Zhao C, Yan S, Luo Y, Song Y, Xia X. Analyzing resistome in soil and Human gut: a study on the characterization and risk evaluation of antimicrobial peptide resistance. Front Microbiol. 2024 Mar 25;15:1352531.
2)      Huang X, Hou J, Le X, Hou Y, Yang L, Li Q, Wang B, Xia X. Diversity of astroviruses in wild animals in Yunnan province, China. Virol J. 2024 Feb 27;21(1):51.
3)      Fan Y, Hou Y, Li Q, Dian Z, Wang B, Xia X. RNA virus diversity in rodents. Arch Microbiol. 2023 Dec 1;206(1):9.
4)      Shah T, Hou Y, Jiang J, Shah Z, Wang Y, Li Q, Xu X, Wang Y, Wang B, Xia X. Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies. Front Microbiol. 2023 Nov 3;14:1283453.
5)      Liu L, Li M, Liu G, He J, Liu Y, Chen X, Tu Y, Lin J, Feng Y, Xia X.  A novel, highly sensitive, one-tube nested quantitative real-time PCR for Brucella in human blood samples. Microbiol Spectr. 2023 Dec 12;11(6):e0058223.
6)      Liu M, Zhao T, Zhang Y, Zhang AM, Geng J, Xia X. The incidence of hepatocellular carcinoma and clearance of hepatitis B surface for CHB patients in the indeterminate phase: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2023 Sep 12;13:1226755.
7)      Shah T, Wang Y, Wang Y, Li Q, Zhou J, Hou Y, Wang B, Xia X. A Comparative Analysis of the Stomach, Gut, and Lung Microbiomes in Rattus norvegicus. Microorganisms. 2023 Sep 21;11(9):2359.
8)      Jia Y, Zou X, Yue W, Liu J, Yue M, Liu Y, Liu L, Huang P, Feng Y, Xia X. The distribution of hepatitis C viral genotypes shifted among chronic hepatitis C patients in Yunnan, China, between 2008-2018. Front Cell Infect Microbiol. 2023 Jul 11;13:1092936.
9)      Shah T, Li Q, Wang B, Baloch Z, Xia X. Geographical distribution and pathogenesis of ticks and tick-borne viral diseases. Front Microbiol. 2023 May 24;14:1185829.
10)   Mahmood F, Xu R, Awan MUN, Jia T, Zhang T, Shi W, Liu M, Han Q, Zhu Q, Zhang Q, Song Y, Xia X, Zhang J. Transcriptomics based identification of S100A3 as the key anti-hepatitis B virus factor of 16F16. Biomed Pharmacother. 2023 Jul;163:114904.
11)   Qu L, Li X, Huang B, Liu Y, Li Q, Shah T, Ning Y, Li J, Lu Y, Yan L, Wang B, Xia X. Identification and Characterization of Jingmen Tick Virus in Ticks from Yunnan Imported Cattle. Vector Borne Zoonotic Dis. 2023 May;23(5):298-302.
12)   Liu J, Li J, Wang B, Liu Y, Liu L, Liu Y, Feng Y, Qin W, Xia X. Characterization of a newly emerging HCV subtype 6xk among Burmese travelers arriving at Ruili Port in Yunnan, China. J Infect. 2023 Jul;87(1):72-75.
13)   Zhang L, Ye X, Liu Y, Zhang Z, Xia X, Dong S. Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia. Front Pharmacol. 2023 Apr 7;14:1132388.
14)   Li Q, Shah T, Wang B, Qu L, Wang R, Hou Y, Baloch Z, Xia X. Cross-species transmission, evolution and zoonotic potential of coronaviruses. Front Cell Infect Microbiol. 2023 Jan 6;12:1081370.
15)   Liu S, Li Y, Song Y, Wu X, Baloch Z, Xia X. The diversity of vaginal microbiome in women infected with single HPV and multiple genotype HPV infections in China. Front Cell Infect Microbiol. 2022 Dec 19;12:642074.
16)   Xu X, Luo Y, He C, Dian Z, Mi H, Yang J, Feng Y, Miao Z, Xia X. Increased Risk of Neurological Disease Following Pediatric Rotavirus Infection: A Two-Center Case-Control Study. J Infect Dis. 2023 May 29;227(11):1313-1321.
17)   Huang X, Zhou J, Hou Y, Wang R, Li Q, Wang Y, Yuan R, Chen P, Wang B, Xia X. Diversity and Genetic Characteristics of Astroviruses from Animals in Yunnan Province. Viruses. 2022 Oct 12;14(10):2234.
18)   Zhao C, Yan S, Song Y, Xia X. Roles of Antimicrobial Peptides in Gynecological Cancers. Int J Mol Sci. 2022 Sep 3;23(17):10104.
19)   Shah T, Shah Z, Yasmeen N, Baloch Z, Xia X. Pathogenesis of SARS-CoV-2 and Mycobacterium tuberculosis Coinfection. Front Immunol. 2022 Jun 16;13:909011.
20)   Xie P, Fang Y, Baloch Z, Yu H, Zhao Z, Li R, Zhang T, Li R, Zhao J, Yang Z, Dong S, Xia X. A Mouse-Adapted Model of HCoV-OC43 and Its Usage to the Evaluation of Antiviral Drugs. Front Microbiol. 2022 May 17;13:845269.
21)   Xiao M, Feng Y, Gao L, Yang C, Liu J, He M, Li J, Zhang M, Dong X, Xia X. Characterization of a Newly Emerging HIV-1 Second-Generation Recombinant Form (CRF125_0107) Among Heterosexuals in Yunnan, China. J Infect. 2022 Jun;84(6):e112-e115.
22)   Fang Y, Baloch Z, Zhang W, Hu Y, Zheng R, Song Y, Tai W, Xia X. Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province. Infect Drug Resist. 2022 Mar 16;15:1103-1114.
23)   Xie P, Fang Y, Shen Z, Shao Y, Ma Q, Yang Z, Zhao J, Li H, Li R, Dong S, Wen W, Xia X. Broad antiviral and anti-inflammatory activity of Qingwenjiere mixture against SARS-CoV-2 and other human coronavirus infections. Phytomedicine. 2021 Dec;93:153808.
24)   Li D, Baloch Z, Zhao Y, Bai L, Wang X, Wang G, Zhang AM, Lan K, Xia X. Establishment of Tree Shrew Animal Model for Kaposi's Sarcoma-Associated Herpesvirus (HHV-8) Infection. Front Microbiol. 2021 Sep 16;12:710067.
25)   Jia Y, Yue W, Gao Q, Tao R, Zhang Y, Fu X, Liu Y, Liu L, Feng Y, Xia X. Characterization of a Novel Hepatitis C Subtype, 6xj, and Its Consequences for Direct-Acting Antiviral Treatment in Yunnan, China. Microbiol Spectr. 2021 Sep 3;9(1):e0029721.
26)   Feng Y, Gao Q, Gao L, Zhang M, Liu Y, Xiao M, Dong X, Xia X. Identification of a newly emerging HIV-1 CRF111_01C comprising CRF01_AE and C in Yunnan, China: Genetic characterization and recombinant history. Infect Genet Evol. 2021 Nov;95:105053.
27)   Yang HL, Baloch Z, Xu JW, Sun XD, Lin ZR, Zhou YW, Zhao XT, Lv Q, Xu SY, Ding CL, Chen QY, Tian P, Dung KX, Xia XS, Zhou HN. Malaria: elimination tale from Yunnan Province of China and new challenges for reintroduction. Infect Dis Poverty. 2021 Jul 21;10(1):101.
28)   Baloch Z, Shen Z, Zhang L, Feng Y, Li D, Zhang NN, Deng YQ, Yang C, Sun X, Dai J, Yang Z, Qin CF, Xia X. Recapitulating Zika Virus Infection in Vagina of Tree Shrew (Tupaia belangeri). Front Cell Infect Microbiol. 2021 Jun 25;11:687338.
29)   Shah T, Baloch Z, Shah Z, Cui X, Xia X. The Intestinal Microbiota: Impacts of Antibiotics Therapy, Colonization Resistance, and Diseases. Int J Mol Sci. 2021 Jun 20;22(12):6597.
30)   Gao Q, Feng Y, Gao L, Zhang M, Liu Y, Xiao M, Dong X, Xia X. Genetic characteristics of a New HIV-1 subtype B/C intersubtype circulating recombinant form (CRF118_BC) identified in Yunnan, China. J Infect. 2021 Aug;83(2):237-279.
31)   Yang T, Liang S, Yang S, Lin Y, Dian Z, Zhao T, Su H, Zhang AM, Liu J, Huang B, Zhang Y, Xia X, Wang B, Qin W. Phylogenetic characteristics of HIV among female cross-border travelers in Yunnan province between 2003 and 2012. J Med Virol. 2021 Aug;93(8):5173-5176.
32)   Li J, Gao Q, Zhang M, Liu J, Jia Y, Feng Y, Xia X, Dong X. A newly emerging HIV-1 circulating recombinant form (CRF110_BC) comprising subtype B and C among intravenous drug users in Yunnan, China. J Infect. 2021 Mar;82(3):e8-e10.
33)   Jia Y, Yang C, Zhang M, Yang X, Li J, Liu J, Liu Y, Yang X, Feng Y, Dong X, Xia X. Characterization of eight novel full-length genomes of SARS-CoV-2 among imported COVID-19 cases from abroad in Yunnan, China. J Infect. 2020 Aug;81(2):e96-e98.
34)   Feng Y, Xiao H, Li X, Lu Y, Li J, Zheng M, Lv D, Yuan W, Zhang Z, Zhou Y, Liang Y, Qin W, Xia X. Nonindigenous East/Central/South African genotype of chikungunya virus identified in febrile returning travellers in Yunnan, China. J Infect. 2020 Apr;80(4):469-496.
35)   Yue W, Feng Y, Jia Y, Liu Y, Zhang Y, Geng J, Xia X. Identification of a new HCV subtype 6xi among chronic hepatitis C patients in Yunnan, China. J Infect. 2020 Apr;80(4):469-496.
36)   Shen Z, Li X, Lu Y, Li J, Xiao H, Yuan W, Zhang Z, Zhou Y, Feng Y, Qin W, Xia X. Nonindigenous case of Asian Zika virus lineage in Yunnan, China, 2019. J Infect. 2019 Dec;79(6):612-625.
37)   Ren L, Wang B, Miao Z, Liu P, Zhou S, Feng Y, Yang S, Xia X, Wang K. A correlation analysis of HHV infection and its predictive factors in an HIV-seropositive population in Yunnan, China. J Med Virol. 2020 Mar;92(3):295-301.
38)   Zhang AM, Yang M, Gao L, Zhang M, Jiao L, Feng Y, Dong X, Xia X. The distinct epidemic characteristics of HCV co-infection among HIV-1-infected population caused by drug injection and sexual transmission in Yunnan, China. Epidemiol Infect. 2019 Sep 2;147:e261.
39)   Zhang C, Feng Y, Gao L, Zhang M, Miao J, Dong X, Xia X. Genetic characterization and recombinant history of a novel HIV-1 circulating recombinant form (CRF101_01B) identified in Yunnan, China. Infect Genet Evol. 2019 Sep;73:109-112.
40)   Dong SW, Jiao LS, Yang M, Duan YL, Chen YB, Zhao F, Zhang AM, Liu L, Luo MH, Xia XS. The Susceptibility of Primary Dermis Fibroblasts from the Chinese Tree Shrew to Human Cytomegalovirus Infection. Virol Sin. 2019 Jun;34(3):270-277.
41)   Li D, Song Y, Yang P, Li X, Zhang AM, Xia X. Genetic diversity and drug resistance of Mycobacterium tuberculosis in Yunnan, China. J Clin Lab Anal. 2019 Jun;33(5):e22884.
42)   Zhang L, Shen ZL, Feng Y, Li DQ, Zhang NN, Deng YQ, Qi XP, Sun XM, Dai JJ, Yang CG, Yang ZF, Qin CF, Xia XS. Infectivity of Zika virus on primary cells support tree shrew as animal model. Emerg Microbes Infect. 2019;8(1):232-241.
43)   Zhang NN, Zhang L, Deng YQ, Feng Y, Ma F, Wang Q, Ye Q, Han Y, Sun X, Zhang FC, Qi X, Wang G, Dai J, Xia X, Qin CF. Zika Virus Infection in Tupaia belangeri Causes Dermatological Manifestations and Confers Protection against Secondary Infection. J Virol. 2019 Apr 3;93(8):e01982-18.
44)   Feng Y, Zhang C, Zhang M, Gao L, Miao J, Jia Y, Dong X, Xia X. First report of a novel HIV-1 recombinant form (CRF100_01C) comprising CRF01_AE and C among heterosexuals in Yunnan, China. J Infect. 2018 Dec;77(6):561-571.
45)   Feng Y, Ran J, Feng YM, Miao J, Zhao Y, Jia Y, Li Z, Yue W, Xia X. Genetic diversity of hepatitis B virus in Yunnan, China: identification of novel subgenotype C17, an intergenotypic B/I recombinant, and B/C recombinants. J Gen Virol. 2020 Sep;101(9):972-981.
46)   Wang B, Liang Y, Yang S, Du Y, Xiong LN, Zhao T, Yang F, Qin W, Xia X. Co-Circulation of 4 Dengue Virus Serotypes among Travelers Entering China from Myanmar, 2017. Emerg Infect Dis. 2018 Sep;24(9):1756-1758.
47)   Xuan Q, Liang S, Qin W, Yang S, Zhang AM, Zhao T, Su H, Xia Z, Wang B, Xia X. High prevalence of HIV-1 transmitted drug resistance among therapy-na?ve Burmese entering travelers at Dehong ports in Yunnan, China. BMC Infect Dis. 2018 May 8;18(1):211.
48)   Zhang L, Wei Q, Han Q, Chen Q, Tai W, Zhang J, Song Y, Xia X. Detection of Shigella in Milk and Clinical Samples by Magnetic Immunocaptured-Loop-Mediated Isothermal Amplification Assay. Front Microbiol. 2018 Feb 6;9:94.
49)   Miao J, Ran J, Song Y, Liu Y, Gao L, Miao Z, Zhang C, Feng Y, Xia X. Characterization of a Novel HIV-1 Circulating Recombinant Form, CRF01_AE/B'/C (CRF96_cpx), in Yunnan, China. AIDS Res Hum Retroviruses. 2018 Apr;34(4):393-397.
50)   Ren L, Wang B, Gong K, Liu P, Zhou S, Zhang L, Xia X, Wang K. Epidemiology reveals Zhaotong City as the hub of human immunodeficiency virus type 1 transmission from the Yunnan province to other regions in China. J Gen Virol. 2017 Dec;98(12):3093-3100.
51)   Niu B, Li C, Su H, Li Q, He Q, Liu L, Xue Y, Shen T, Xia X. Glucagon-like peptide-1 receptor agonist exendin-4 protects against interleukin-1β-mediated inhibition of glucose-stimulated insulin secretion by mouse insulinoma β cells. Exp Ther Med. 2017 Sep;14(3):2671-2676.
52)   Wang B, Liang Y, Lu Y, Zhang L, Li Y, Song Y, Qin C, Luo Z, Xia Z, Qin W, Xia X. The importation of the phylogenetic-transition state of Zika virus to China in 2014. J Infect. 2018 Jan;76(1):106-109.
53)   Feng Y, Gao L, Miao J, Zhang M, Zhang C, Wang X, Zhao Y, Zhao J, Min H, Dong X, Xia X. Human infection with a novel H7N9 avian influenza virus in Yunnan, China. J Infect. 2018 Jan;76(1):98-101.
54)   Feng Y, Feng YM, Lu C, Han Y, Liu L, Sun X, Dai J, Xia X. Tree shrew, a potential animal model for hepatitis C, supports the infection and replication of HCV in vitro and in vivo. J Gen Virol. 2017 Aug;98(8):2069-2078.
55)   Yuanyue L, Baloch Z, Yasmeen N, Tao Y, Xiaomei W, Xueshan X. The distribution of human papillomavirus genotypes in cervical cancer and intraepithelial neoplasia lesions among Chinese women in Yunnan Province. J Infect Public Health. 2018 Jan-Feb;11(1):105-110.
56)   Dian Z, Wang B, Fan M, Dong S, Feng Y, Zhang AM, Liu L, Niu H, Li Y, Xia X. Completely genomic and evolutionary characteristics of human-dominant G9P[8] group A rotavirus strains in Yunnan, China. J Gen Virol. 2017 Jun;98(6):1163-1168.
57)   Zhao Y, Feng Y, Ding X, Dong S, Zhang H, Ding J, Xia X. Identification of a novel hypertrophic cardiomyopathy-associated mutation using targeted next-generation sequencing. Int J Mol Med. 2017 Jul;40(1):121-129.
58)   Miao Z, Xie Z, Miao J, Ran J, Feng Y, Xia X. Regulated Entry of Hepatitis C Virus into Hepatocytes. Viruses. 2017 May 9;9(5):100.
59)   Baloch Z, Yasmeen N, Li Y, Ma K, Wu X, Yang SH, Xia X. Prevalence and risk factors for human papillomavirus infection among Chinese ethnic women in southern of Yunnan, China. Braz J Infect Dis. 2017 May-Jun;21(3):325-332.
60)   Miao Z, Gao L, Song Y, Yang M, Zhang M, Lou J, Zhao Y, Wang X, Feng Y, Dong X, Xia X. Prevalence and Clinical Impact of Human Pegivirus-1 Infection in HIV-1-Infected Individuals in Yunnan, China. Viruses. 2017 Feb 15;9(2):28.
61)   Zhang L, Wang B, Liang Y, Feng Y, Dong S, Wang Y, Li Y, Zhang AM, Liu L, Qin W, Xia X. Phylogenetic characteristics of HIV-1 among travelers entering China from Myanmar: A retrospective study. J Med Virol. 2017 Aug;89(8):1404-1411.
62)   Ma K, Baloch Z, He TT, Xia X. Alcohol Consumption and Gastric Cancer Risk: A Meta-Analysis. Med Sci Monit. 2017 Jan 14;23:238-246.
63)   Zhang AM, Zhang CL, Song Y, Zhao P, Feng Y, Wang B, Li Z, Liu L, Xia X. Genetic variations of the NPC1L1 gene associated with hepatitis C virus (HCV) infection and biochemical characteristics of HCV patients in China. Int J Infect Dis. 2016 Dec;53:6-11.
64)   Li Y, Miao J, Miao Z, Song Y, Wen M, Zhang Y, Guo S, Zhao Y, Feng Y, Xia X. Identification of a Novel HIV Type 1 Circulating Recombinant Form (CRF86_BC) Among Heterosexuals in Yunnan, China. AIDS Res Hum Retroviruses. 2017 Mar;33(3):279-283.
65)   Dian Z, Fan M, Wang B, Feng Y, Ji H, Dong S, Zhang AM, Liu L, Niu H, Xia X. The prevalence and genotype distribution of rotavirus A infection among children with acute gastroenteritis in Kunming, China. Arch Virol. 2017 Jan;162(1):281-285.
66)   Baloch Z, Li Y, Yuan T, Feng Y, Liu Y, Tai W, Liu L, Wang B, Zhang AM, Wu X, Xia X. Epidemiologic characterization of human papillomavirus (HPV) infection in various regions of Yunnan Province of China. BMC Infect Dis. 2016 May 26;16:228.
67)   Zhao Y, Cao H, Song Y, Feng Y, Ding X, Pang M, Zhang Y, Zhang H, Ding J, Xia X. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system. Int J Mol Med. 2016 Jun;37(6):1511-20.
68)   Feng Y, Guan W, Yuan B, Wang Y, Li Z, Song Y, Li S, Yang Z, Zhong N, Zhang Y, Xia X. Emergence of triple-subtype reassortants of fatal human H5N6 avian influenza virus in Yunnan, China. J Infect. 2016 Jun;72(6):753-756.
69)   Rui Z, Dehua L, Hua N, Yue F, Yunmin X, Jianhua L, Xueshan X. Carbapenemase-Producing Enterobacteriaceae in Yunnan Province, China. Jpn J Infect Dis. 2016 Nov 22;69(6):528-530.
70)   Zheng R, Zhang Q, Guo Y, Feng Y, Liu L, Zhang A, Zhao Y, Yang X, Xia X. Outbreak of plasmid-mediated NDM-1-producing Klebsiella pneumoniae ST105 among neonatal patients in Yunnan, China. Ann Clin Microbiol Antimicrob. 2016 Feb 19;15:10.
71)   Song Y, Feng Y, Miao Z, Wang B, Yang M, Zhang AM, Liu L, Xia X. Near-Full-Length Genome Sequences of a Novel HIV-1 Circulating Recombinant Form, CRF01_AE/B'/C (CRF78_cpx), in Yunnan, China. AIDS Res Hum Retroviruses. 2016 Jun;32(6):601-6.
72)   Baloch Z, Yue L, Yuan T, Feng Y, Tai W, Liu Y, Wang B, Li X, Liu L, Zhang AM, Wu X, Xia X. Status of Human Papillomavirus Infection in the Ethnic Population in Yunnan Province, China. Biomed Res Int. 2015;2015:314815.
73)   Wang B, Yang H, Feng Y, Zhou H, Dai J, Hu Y, Zhang L, Wang Y, Baloch Z, Xia X. The distinct distribution and phylogenetic characteristics of dengue virus serotypes/genotypes during the 2013 outbreak in Yunnan, China: Phylogenetic characteristics of 2013 dengue outbreak in Yunnan, China. Infect Genet Evol. 2016 Jan;37:1-7.
74)   Feng Y, Feng YM, Feng Y, Lu C, Liu L, Sun X, Dai J, Xia X. Identification and Characterization of Liver MicroRNAs of the Chinese Tree Shrew via Deep Sequencing. Hepat Mon. 2015 Oct 3;15(10):e29053.
75)   Zhao Y, Feng Y, Zhang YM, Ding XX, Song YZ, Zhang AM, Liu L, Zhang H, Ding JH, Xia XS. Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy. Int J Mol Med. 2015 Dec;36(6):1479-86.
76)   Baloch Z, Yuan T, Wang B, Tai W, Feng Y, Liu Y, Li X, Feng Y, Liu L, Zhang AM, Wu X, Xia X. Ethnic and geographic variations in HPV prevalence and genotype distribution in north-western Yunnan, China. J Med Virol. 2016 Mar;88(3):532-40.
77)   Zhao Y, Feng Y, Zhang YM, Ding XX, Song YZ, Zhang AM, Liu L, Zhang H, Ding JH, Xia XS. Targeted Next-Generation Sequencing Reveals Hot Spots and Doubly Heterozygous Mutations in Chinese Patients with Familial Cardiomyopathy. Biomed Res Int. 2015;2015:561819.
78)   Zhang J, Jin Z, Sun T, Jiang Y, Han Q, Song Y, Chen Q, Xia X. Prokaryotic Expression, Purification, and Polyclonal Antibody Production of a Truncated Recombinant Rabies Virus L Protein. Iran J Biotechnol. 2015 Jun;13(2):18-24.
79)   Wang B, Liang Y, Feng Y, Li Y, Wang Y, Zhang AM, Baloch Z, Liu L, Qin W, Xia X. Prevalence of human immunodeficiency virus 1 infection in the last decade among entry travelers in Yunnan Province, China. BMC Public Health. 2015 Apr 11;15:362.
80)   Wang B, Li Y, Feng Y, Zhou H, Liang Y, Dai J, Qin W, Hu Y, Wang Y, Zhang L, Baloch Z, Yang H, Xia X. Phylogenetic analysis of dengue virus reveals the high relatedness between imported and local strains during the 2013 dengue outbreak in Yunnan, China: a retrospective analysis. BMC Infect Dis. 2015 Mar 21;15:142.
81)   Wang Y, Liang Y, Feng Y, Wang B, Li Y, Wu Z, Zhang J, Baloch Z, Zhang AM, Liu L, Qin W, Xia X. HIV-1 prevalence and subtype/recombinant distribution among travelers entering China from Vietnam at the HeKou port in the Yunnan province, China, between 2003 and 2012. J Med Virol. 2015 Sep;87(9):1500-9.
82)   Wang B, Feng Y, Li Z, Duan H, Zhao T, Zhang A, Liu L, Baloch Z, Xia X. Distribution and diversity of hepatitis B virus genotypes in Yunnan, China. J Med Virol. 2014 Oct;86(10):1675-82.
83)   Feng Y, Liu L, Feng YM, Zhao W, Li Z, Zhang AM, Song Y, Xia X. GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C. Hepat Mon. 2014 Mar 3;14(3):e14169.
84)   Zhang AM, Ma K, Song Y, Wang B, Feng Y, Liu L, Xia X. Genetic polymorphisms of the IFNλ genes are associated with biochemical features in Han Chinese with HCV infection from Yunnan Province, China. Infect Genet Evol. 2014 Jan;21:161-5.
85)   Feng Y, Zhao W, Feng Y, Dai J, Li Z, Zhang X, Liu L, Bai J, Zhang H, Lu L, Xia X. A novel genotype of GB virus C: its identification and predominance among injecting drug users in Yunnan, China. PLoS One. 2011;6(10):e21151.
6、获得专利
1)   夏雪山,黄怡,缪志江,冯悦,刘丽.疱疹病毒八个型的两管四重荧光定量PCR分型检测试剂.CN117737307A.2024.03.22
2)   张阿梅,孙宁宁,夏雪山,董书维.用于检测OPAI基因突变位点的引物组合就其应用.CN117757927A.2024.03.26
3)   张阿梅,施秋梅,夏雪山,董书维.人冠状病毒主要蛋白酶3CLpro的活性报告质粒及其应用.CN117363654A.2024.01.09
4)   冯悦,吴甜,刘阳,刘高文,夏雪山.检测肺炎支原体及其大环内酯类药物耐药位点的引物组合.CN116287343A.2023.06.23
5)   王炳辉,宁玉婷,夏雪山,侯宇彤,刘丽.一种蜱源荆门蜱病毒基因组扩增引物组、扩增方法和应用.CN116716437A.2023.09.08
6)   张阿梅,施秋梅,夏雪山,董书维.筛选人冠状病毒主要蛋白酶3CLpro抑制剂的方法.CN116840201A.2023.10.03
7)   夏雪山,张敏,冯悦,刘高文. 检测集合分枝杆菌氟喹诺酮耐药突变物组合.CN116769939A.2023.09.19
7、获得重要奖励
1)   夏雪山,第二获奖人,云南省科技进步一等奖,树鼩饲养繁殖种群建立及其在HCV动物模型中的应用,2013,2012DC127-R-002;
2)   夏雪山,第二获奖人,中国实验动物学会科学技术一等奖,树鼩实验动物化种群建立及应用, 2014,20146501-1-P1502;
3)   夏雪山,第一获奖人,云南省自然科学二等奖,云南省血源传播肝炎病毒多基因型流行与新基因型发现,2017,2016MA257-R-001;
4)   夏雪山,第一获奖人,云南省科技进步一等奖,云南重要跨境传染病传播特性与口岸卫生检疫技术体系构建及应用, 2019,2018NC211-R-001;
5)   夏雪山,第一获奖人,云南省自然科学二等奖,宿主因素对慢性丙型肝炎形成的影响及机制研究, 2021,2020NA005-R-001。




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