徐祥 研究员
招生层次:硕士/博士研究生
招生专业:100216康复医学与理疗学/105500药学(专业学位)
专业类型:学术型/专业型
研究方向:干细胞与再生医学
邮 箱:/xiangxu@ymail.com
个人简介:
1991年09月-1995年07月,第三军医大学临床医学检验系,学士
1998年09月-2002年07月,第三军医大学野战外科研究所,硕士
2003年09月-2006年07月,第三军医大学野战外科研究所,博士
2007年01月-2009年11月,美国匹兹堡大学肿瘤研究所,访问学者,博士后
1995年08月–2000年08月,第三军医大学野战外科研究所,实习研究员
2000年08月–2006年08月,第三军医大学野战外科研究所,助理研究员
2006年08月-至今,第三军医大学野战外科研究所,历任副研究员、研究员、主任,博士研究生导师
主要研究方向及成果:
徐祥教授为重庆英才创新领军人才,重庆市中青年干细胞与再生医学卓越团队带头人。创伤烧伤与复合伤国家重点实验室中心实验室主任,陆军军医大学陆军特色医学中心(大坪医院)干细胞与再生医学科主任,中国医药质量管理协会细胞质量控制与研究专业委员会副主任委员、中国医药质量管理协会细胞和基因治疗药物质量研究专业委员会副主任委员、中国中西医结合学会第一界干细胞与再生医学专业委员会常委和重庆市干细胞临床研究专家委员会委员。长期从事干细胞与再生医学基础与临床转化应用研究,专注间充质干细胞(MSCs)炎症/免疫调节机制及临床转化应用治疗炎性/免疫相关性疾病研究。主持了包括国家重点研发计划分课题、国家“973”项目分课题、国家自然科学基金(6项)和省部级重大研究项目30余项,发表SCI论文70篇,单篇最高影响因子37.3分,累计影响因子286分,第一发明人获授权发明专利6项,CIK培养基、NK培养基和脐带间充质干细胞培养基完成3款I类医疗器械备案注册,以主要完成人获国家科技进步二等奖和中华医学科技一等奖各1项。
代表性论文:
(1) Quan Chen?, Luoquan Ao?, Qing Zhao, Lu Tang, Yanli Xiong, Yuchuan Yuan, Xiaofeng Wu, Zhan Li, Wei Xing, Wei Guo, Xueting Hu, Chengxiu Pu, Huaping Liang,Songguo Zheng, Qizhou Lian, Di Lu, Weijun Wan#,Xiang Xu#.WTAP/YTHDF1-mediated m6A modification amplifies IFN--induced immunosuppressive properties of human MSCs.J Adv Res.2024,online.(#Corresponding author,IF:11.4)(中科院分区综合期刊1区;JCR综合期刊Q1)
(2) Zhou Chen,Xuewei Xia, Mengwei Yao,Yi Yang,Xiang Ao,Zhaoqi Zhang,Li Guo,Xiang Xu#.The dual role of mesenchymal stem cells in apoptosis regulation. Cell Death Dis. 2024 Apr 6;15(4):250.(#Corresponding author,IF:8.1)(中科院分区生物学1区;JCR医学Q1)
(3) Xue-Ting Hu*, Xiao-Feng Wu*, Lu-Min Sui, Luo-Quan Ao, Cheng-Xiu Pu, Mu Yuan, Wei Xing#, Xiang Xu#.The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750. J Dermatol Sci. 2024 Mar;113(3):93-102.(#Corresponding author,IF:3.8)(中科院分区皮肤病学2区;JCR皮肤病学Q1)
(4) Xuewei Xia,Peixin Shen,Guomei Yang,Mengwei Yao,Xiaofeng Wu,Lina Lyn,Yanji He,Zhuxin Li,Wei Wang,Yi Yang,Xiang Ao,Chuanjiang Xia,Zhuo Chen#,Xiang Xu#. The proliferation/migration ability mediated by CD151/PI3K/AKT pathway determines the therapeutic effect of hUC-MSCs transplantation on rheumatoid arthritis. Clinical and Experimental Hypertension.2024 June, 46(1):2366270.(#Corresponding author,IF:1.5)(中科院分区医学4区;JCR医学Q4)
(5) Yuan Mu,Hu Xueting,Xing Wei,Wu Xiaofeng,Pu Chengxiu,Guo Wei,Zhu Xiyan,Yao Menwei,Ao Luoquan,Li Zhan,Xu Xiang#. B2M is a biomarker associated with immune infiltration in High altitude pulmonary edema. Comb Chem High Throughput Screen. 2024;27(1):168-185. ( #Corresponding author,IF: 1.6) (中科院分区医学4区)
(6) Zhuo chen*,Mengwei Yao*,Xiang Xu#,Lingjing Zuo#.The expression mechanism of PD-L1 and its role in immunomodulatory ability of MSCs. Chin J Traumatol. 2024 Jan;27(1):1-10 . ( #Corresponding author,IF: 1.8) (中科院分区医学4区)
(7) Chunyan Zhu, Lingjie Ke, Xiang Ao, Ying Chen, Hongwei Cheng, Huhu Xin, Xiang Xu#, Xian-Jun Loh, Zibiao Li, Haiyan Lyu, Qi Wang, Dandan Zhang, Yuan Ping#, Caisheng Wu#, Yun-Long Wu#.Injectable Supramolecular Hydrogels for In Situ Programming of Car-T Cells toward Solid Tumor Immunotherapy. Advanced Materials. 2023 Nov 10:e2310078.doi: 10.1002/adma.202310078. ( #Co-Corresponding author,IF:27.4) (中科院分区医学1区;JCR医学Q1)
(8) Xuewei Xia *, Yongchun Zeng*, Zhuxin Li, Hao Luo Wei Wang, Yanji He, Bingjun Lu, Jingwen Guo, Ken Chen#, Xiang Xu#. Effect of GRK4 on renal gastrin receptor regulation in hypertension, Clinical and Experimental Hypertension, 2023, 45(1), 2245580.(#Corresponding author,IF:1.5)(中科院分区医学4区;JCR医学Q4)
(9) Xiaohui Wang*, Wei Qiu2*, Haoyu Liu, Min He, Wei He, Zhan Li, Zhiqiang Wu, Weidong Han, Xiang Xu#, Ping Chen#.The inducible secreting TLR5 agonist CBLB502 enhances the antitumor activity of CAR133-NK92 cells in colorectal cancer. Cancer Biology & Medicine. 2023 Sep 19;20(9):662-81. ( #Corresponding author,IF: 5.6) (中科院分区医学2区;JCR医学Q2)
(10) Weiqiang Li, Qianqian Liu, Jinchao Shi, Xiang Xu#,Jinyi Xu#. The Role of TNF-αin the Fate Regulation and Functional Reprogramming of Mesenchymal Stem Cells in an Inflammatory Microenvironment. Frontiers in immunology,2023,DOI: 10.3389/fimmu.2023.1074863. ( #Corresponding author,IF: 5.7) (中科院分区免疫学2区;JCR免疫学Q1)
(11) Shi-Dan Li, Wei Xing, Shao-Chuan Wang, You-Bin Li, Hao Jiang, Han-Xuan Zheng, Xiao-Ming Li, Jing Yang, De-Bin Guo, Xiao-Yu Xie, Ren-Qing Jiang, Chao Fan, Lei Li, Xiang Xu#, Jun Fei#.Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing. Experimental & Molecular Medicine, 2023, DOI : 10.1038/s12276-023-00942-0. ( #Corresponding author,IF: 9.5;2022:12.8) (中科院分区生物化学与分子生物学2区;JCR生物化学与分子生物学Q1)
(12) Yu Wang, Xia Zhou, Shunyao Zhu, Xinlin Wei, Nazi Zhou, Xueyuan Liao, Yanhua Peng, Yaping Tang, Lin Zhang, Xi Yang, Yang Li, Xiang Xu#, Jie Tao#, Rui Liu#. Cryoprinting of Nanoparticle-Enhanced Injectable Hydrogel with Shape-memory properties. Materials & Design 223 (2022) 111120. ( #Co-Corresponding author,IF: 8.4) (中科院分区材料科学1区;JCR材料科学Q1)
(13) Mengwei Yao,Zhuo Chen, Xiao He,Jiaoyue Long, Xuewei Xia, Zhan Li,Yu Yang, Luoquan Ao,Wei Xing,Qizhou Lian,Huaping Liang#, Xiang Xu#. Cross talk between glucose metabolism and immunosuppression in IFN--primed mesenchymal stem cells. Life Science Alliance.2022;5(12):e202201493. ( #Corresponding author,IF: 4.4) (中科院分区生物学2区;JCR细胞生物学Q1)
(14) Xiao-hui Wang*, Wei Guo*, Wei Qiu*, Luo-quan Ao, Meng-wei Yao,Wei Xing,Yang Yu, Quan Chen, Xiao-feng Wu, Zhan Li, Xue-ting Hu#,Xiang Xu#. Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution. International Journal of Biological Sciences.2022;18:4388-4399. ( #Corresponding author,IF: 9.2) (中科院分区生物大类2区;JCR细胞生物学Q1)
(15) Li Shidan,Jiang Hao,Xing Wei,Wang Shaochuan,Zhang Yao,Li Youbin,Mao Chengyi,Zeng Delian,Lan Ping,TangDongqin,Zhan Jijie,Li Lei,Xu Xiang#,Fei Jun#.A Clinical Diagnostic Study: Fibulin-2 is a Novel Promising Biomarker for Predicting Infection. Infect Dis Ther. 2022 Mar 18. pii: 10.1007/s40121-022-00622-y. (#Corresponding author,IF: 5.4) (中科院分区医学大类3区;JCR传染病学Q1)
(16) Weijun Wang*,Xiang Ao*, Quang Chen, Yang Yu, Luoquan Ao, Luming Sui,Mengwei Yao,Wei Xing, Xiaofen Wu, Zhan Li, Xueting Hu, Wei Guo, Donglin Luo#,Xiang Xu#. METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer. Mol Cancer. 2022 Feb 23;21(1):60. doi: 10.1186/s12943-021-01447-y.(#Corresponding author,IF: 37.4) (中科院分区医学大类1区;JCR肿瘤学Q1)(Cited:24)
(17) Yi Yang*, Xiao He*, Mengwei Yao, Wei Xing, Luoquan Ao, Joseph A. Bellanti, Songguo Zheng, Xiang Xu#. Response to:‘Correspondence to:‘Combination of human umbilical cord mesenchymal stem cell transplantation with IFN-γtreatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis’’by Ma et al. Ann Rheum Dis. 2022 Oct;81(10):e207. doi: 10.1136/annrheumdis-2020-218762. ( Corresponding author,IF:27.4) (中科院分区医学大类1区;JCR免疫学Q1)
(18) Zhengcheng Wang*,Xiang Ao*, Zhilin Shen,Luoquan Ao,Xiaofeng Wu,Wei Guo,Wei Xiang,Min He, Hongfeng Yuan, Jianhua Yu, Ling Li#, Xiang Xu#. TNF-αaugments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell. International Journal of Biological Sciences.2021; 17(11): 2683-2702. ( #Corresponding author,IF: 10.75) (中科院分区生物大类2区;JCR细胞生物学Q1)(Cited:32)
(19) Xiao He*, Yi Yang*, Mengwei Yao, Lei Yang, Luoquan Ao, Xueting Hu, Zhan Li, Xiaofeng Wu, Yan Tan, Wei Xing, Wei Guo, Joseph A. Bellanti, Songguo Zheng#, Xiang Xu#. Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-γtreatment synergistically improves the clinical outcomes of rheumatoid arthritis patients. Ann Rheum Dis.2020, Oct;79(10):1298-1304. ( #Corresponding author,IF: 27.4) (中科院分区医学大类1区;JCR免疫学Q1) ( Cited:30)
(20) Zhan Li, Yuqing Song, Peisong Yuan, Wei Guo, Xueting Hu, Wei Xing, Luoquan Ao, Yan Tan, Xiaofeng Wu, Xiang Ao, Xiao He, Dongpo Jiang#, Huaping Liang#, xiang xu#. Antibacterial fusion protein BPI21/LL-37 modification enhances the therapeutic efficacy of human umbilical cord mesenchymal stem cells in sepsis. Mol Ther. 2020 May 15. pii: S1525-0016(20)30248-3. doi: 10.1016/j.ymthe.2020.05.014.(#Corresponding author,IF:11.45) (中科院分区医学大类1区;JCR医学Q1)(Cited:3)
(21) Xue-ting Hu*; Wei Xing*; Rong-sen Zhao; Yan Tan; Xiao-feng Wu; Luo-quan Ao; Zhan Li; Meng-wei Yao; Mu Yuan; Wei Guo; Shang-ze Li; Jian Yu; Xiang Ao#; Xiang Xu#.HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer. Journal of Experimental & Clinical Cancer Research,2020,39(1):270. ( # Corresponding author,IF: 11.16) (中科院JCR分区医学大类1区;JCR肿瘤学Q1)(Cited:68)
(22) Xuanfei Li,Junyu Zhu,Lixing Tian,Xiaoyuan Ma,Xia Fan,Li Luo,Jing Yu,Yu Sun,Xue Yang,Wanqi Tang,Wei Ma,Jun Yan, Xiang Xu#,Huaping Liang#. Agmatine protects against the progression of sepsis through the imidazoline I2 receptor-RSK2-NF-kB signaling pathway. Crit Care Med. 2020,48(1):e40-e47. (#Corresponding author,IF:7.598) (中科院分区医学大类1区;JCR危重病医学Q1)(Cited:7)
(23) Wei Guo*, Wei Qiu*,Xiang Ao*, Xiao He,Tian-chen An, Luo-quan Ao, Xue-ting Hu, Zhan Li, Ming Zhu,Xiangyun Li,Wei Xing#,Xiang Xu#. Low-concentration DMSO accelerates skin wound healing by AKT/mTOR-mediated cell proliferation and migration in diabetic mice. BRIT J PHARMACOL,2020,Jul;177(14):3327-3341.(#Corresponding author,IF: 8.739) (中科院分区药理学1区;JCR药理学Q1)(Cited:10)
(24) Xiao-hui Wang, Zhi-qiang Wu, Wei Qiu, Ping Chen, Xiang Xu#, Wei-dong Han#. Programming CAR T cells to enhance antitumor efficacy through remodeling of the immune system. Frontiers of Medicine. 2020 Aug 13. pii: 10.1007/s11684-020-0746-0. (#Corresponding author,IF: 4.592) (中科院分区医学大类3区;JCR医学Q1) ( Cited:7)
(25) J Li,Q.S Ran,B Hao,X Xu#,H.F Yuan#.Transsphenoidal optic canal decompression for traumatic optic neuropathy assited by a computed tomography image postprocessing Technique.Journal of Ophthalmology. 2020 Aug 12;2020:1870745. (#Corresponding author,IF: 1.909) (中科院JCR分区医学大类4区;JCR医学Q3)(Cited:2)
(26) Jia Li,Xu Bai, Xiaoyue Guan, Hongfeng Yuan#, Xiang Xu#. Treatment of optic canal decompression combined with umbilical cord mesenchymal stem (stromal) cells for indirect traumatic optic neuropathy: a phase 1 clinical trial. Ophthalmic Research. 2021;64(3):398-404. ( #Corresponding author,IF:2.892) (中科院分区医学大类4区;JCR眼科学Q3)(Cited:1)
(27) Xiao he; Meng-Wei Yao; Ming Zhu; Dong-Lan Liang; Wei Guo; Yi Yang; Rong-Seng Zhao; Ting-Ting Ren; Xiang Ao; Wei Wang; Chun-Yu Zeng; Hua-Ping Liang; Dong-po Jiang; Jian Yu; xiang xu#. High glucose protects mesenchymal stem cell from metformin-induced apoptosis through AMPK-mediated mTOR pathway. Scientific Reports, (2019) 9:17764 | https://doi.org/10.1038/s41598-019-54291-y. (#Corresponding author,IF:3.998) (中科院分区综合期刊3区;JCR综合分区Q1) ( Cited:5)
(28) Xiang Ao, Yu Yang, Weiqiang Li, Yan Tang,Wei Qiu, Luo-quan Ao, Xue-ting Hu, Zhan Li, Xiao-Feng Wu, Xiao He, Jianchuan Xia, Xiang Xu#,Jian-xing Guo#. Anti-αFR CAR-engineered NK-92 cells display potent cytotoxicity againstαFR-positive ovarian cancer. Journal of Immunotherapy,2019, 42(8):284-296. (#Co-Corresponding author,IF:4.11) (中科院分区医学大类2区;JCR免疫学Q2) ( Cited:34)
(29) Xiao he; Meng-Wei Yao; Ming Zhu; Dong-Lan Liang; Wei Guo; Yi Yang; Rong-Seng Zhao; Ting-Ting Ren; Xiang Ao; Wei Wang; Chun-Yu Zeng; Hua-Ping Liang; Dong-po Jiang; Jian Yu; xiang xu#. Metformin induces apoptosis in mesenchymal stem cells and dampens their therapeutic efficacy in infarcted myocardium. Stem Cell Research & Therapy,2018,9:306.https://doi.org/10.1186/s13287-018-1057-0. # Corresponding author ,IF: 4.627) (中科院分区医学大类2区;JCR细胞生物学Q1) ( Cited:14)
(30) Daqian Gu; Xiang Ao; Yu Yang; Zhuo Chen; Xiang Xu#. Soluble Immune Checkpoints in Cancer: Production, Function and Biological Significance. J Immunother Cancer. 2018 Nov 27;6(1):132. doi: 10.1186/s40425-018-0449-0. (#Corresponding author,IF:8.676)(中科院分区医学大类1区;JCR免疫学Q1) (Cited:121次)
(31) Xiao He,Shanmu Ai,Wei Guo,Yi Yang,Zhengguo Wang,Dongpo Jiang#,Xiang Xu#.Umbilical cord-derived mesenchymal stem (stromal) cellsfor treatment of severe sepsis:a phase 1 clinical trial. Transl Res. 2018 Sep;199:52-61. (#Corresponding author,IF:4.915)(中科院分区医学实验技术1区;JCR医学Q1)(Cited:32次)
(32) Yi Yang; Xiao He; Rongseng Zhao; Wei Guo; Ming Zhu; Wei Xing; Dongpo Jiang; Chongyang Liu#; xiang xu#.Serum IFN-γLevels Predict the Therapeutic Effect of Mesenchymal Stem Cell Transplantation in Active Rheumatoid Arthritis . J Transl Med. 2018 Jun 15;16(1):165. doi: 10.1186/s12967-018-1541-4. (#Corresponding author, IF:4.098)(中科院分区医学大类2区;JCR医学Q2)(Cited:25次)
(33) M Zhu, X He, X-h Wang, W Qiu, W Xing, W Guo, T-c An, L-q Ao, X-t Hu, Z Li, X-p Liu, N Xiao, J Yu, H Huang#, X Xu#. Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications. Diabetologia. 2017 Sep;60(9):1822-1833. doi: 10.1007/s00125-017-4316-1. Epub 2017 Jun 3. ( #Corresponding author,IF:6.08) (中科院分区医学大类1区;JCR医学Q1)(Cited:16次)
(34) Li X,Li M,Ruan H,Qiu W,Xu X#,Zhang L,Yu J#. Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget,2017,8(6):9280-9292. (#Corresponding author,IF:5.128) (Cited:9次)
(35) Ming Zhu, Wen-Qiu Huang, Wei Qiu, Fang-Qiang Zhu, Wei Xing, Min-Jia Chen, Tian-Chen An, Luo-Quan Ao, Xiang Xu#, Hong Huang#.Curcumin protects mesenchymal stem cells against oxidative stress-induced apoptosis via Akt/mTOR/p70S6K pathway. International Journal of Clinical and Experimental Pathology, 2017, 10(6): 6655-6664.( #Corresponding author,IF:1.396) (中科院分区医学大类4区;JCR医学Q4)
(36) Jiaoyan Han, Jiao Song, Xiangyun Li, Ming Zhu, Wei Guo, Wei Xing, Rongshen Zhao, Xiao He, Xiaoping Liu, Shali Wang, Yunyun Li, Hong Huang#, Xiang Xu#. Ligustrazine Suppresses the Growth of HRPC Cells through the Inhibition of Cap-Dependent Translation Via Both the mTOR and the MEK/ERK Pathways.Anti-Cancer Agents in Medicinal Chemistry.2015;15(6):764-772. (#Corresponding author,IF:2.722) (中科院分区医学大类3区;JCR医学Q3)(cited:16次)
(37) Wei Xing&, Wei Guo&, Cun-Hua Zou,Ting-Ting Fu, Xiang-Yun Li, Ming Zhu, Jun-Hua Qi, Jiao Song, Chen-Hui Dong, Zhuang Li, Yong Xiao, Pei-Song Yuan, Hong Huang#, Xiang Xu#.Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J Dermatol Sci. 2015 Aug;79(2):101-9. doi: 10.1016/j.jdermsci.2015.03.016. (#Corresponding author,IF:3.739) (中科院分区医学大类2区;;JCR皮肤病Q1) (cited:52次)
(38) Hong Huang,Wenhui Cui,Wei Qiu, Ming Zhu, Rongshen Zhao, Dengfen Zeng, Chenhui Dong,Xiaohui Wang, Wei Guo,Wei Xing,Xiangyun Li, Lei Li, Yan Tan, Xiaofeng Wu, Lizhao Chen,Xiaobing Fu,Donglin Luo, Xiang Xu#.Impaired wound healing results from the dysfunction of the Akt/mTOR pathway in diabetic rats. J Dermatol Sci.2015 Sep;79(3):241-51. doi: 10.1016/j.jdermsci.2015.06.002. Epub 2015 Jun 10(#Corresponding author,IF:3.739) (中科院分区医学大类2区;JCR皮肤病Q1) ( cited:26次)
(39) Chen Li-zhao*,Li Xiang-yun*,Huang Hong,Xing Wei,Guo Wei,He Jing,Sun Zhi-ya,Luo An-xiong,Liang Hua-ping,Hu Jing,Xu Yun-sheng#,Wang Zheng-guo#,Xu Xiang#. SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. PLoS One. 2014 Jun 27;9(6):e100457. doi: 10.1371/journal.pone. 0100457.( #Corresponding author,IF: 3.534) (中科院分区综合科学3区;JCR综合科学Q2) (cited:7)
(40) Hong-Feng Yuan*, Hong Huang*, Xiang-Yun Li, Wei Guo, Wei Xing, Zhi-Ya Sun, Hua-Ping Liang, Jian Yu, Dong-Feng Chen, Zheng-Guo Wang, Jin Hao#,Xiang Xu#. A Dual AP-1 and SMAD Decoy ODN Suppresses Tissue Fibrosis and Scarring in Mice. Journal of Investigative Dermatology, 2013;133(4):1080-7. (#Corresponding author,IF:6.372) (中科院分区皮肤病学1区;JCR皮肤病Q1) (cited:15)
(41) Xiang Xu*,Fangqiang Zhu*,Meng Zhang,Dengfen Zeng,Donglin Luo,Guodong Liu,Wenhui Cui,Shali Wang,Wei Guo,Wei Xing,Huaping Liang,Lei Li,Xiaobing Fu,Jianxin Jiang,Hong Huang. Stromal Cell-Derived Factor-1 Enhances Wound Healing through Recruiting Bone Marrow-Derived Mesenchymal Stem Cells to the Wound Area and Promoting neovascularization. Cells Tissues Organs, 2013;197:103–113. (*Co-First author,IF:2.138) (中科院分区生物学4区;JCR解剖学Q2) (cited:105)
(42) Li Na*,Xu Xiang*,Xiao Bin, Zhu En-Dong,Li Bo-Sheng,Liu Zhen,Tang Bin,Zou Quan-Min,Liang Hua-Ping,Mao Xu-Hu. H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. Molecular Biology Reports. 2012;39(4):4655-61.(*Co-first author,IF:2.506) (中科院JCR分区生物学4区;JCR生物学Q4) (cited:53)
(43) Yu Fu Wang*, Xiang Xu*, Xia Fan, Chun Zhang, Qiang Wei, Xi Wang, Wei Guo,Wei Xing, Jian Yu, Jing-Long Yan and Hua-Ping Liang.A Cell-penetrating Peptide Suppresses inflammation by Inhibiting NF-κB Signaling, Molecular Therapy, 2011;19(10):1849-57.(*Co-first author,IF:6.873)(中科院分区医学大类1区;JCR医学Q1) (cited:46)
(44) Xiang Xu*, Jaya Vatsyayan*, Chenxi Gao,Christopher J.Bakkenist,and jing Hu. Sumoylation of eIF4E activates mRNA translation. EMBO Reports,2010; 11(4): 299-304.(*Co-first author,IF:7.822)(中科院分区医学大类1区;JCR医学Q1) (cited:41)
(45) Xiang Xu*, Jaya Vatsyayan*, Chenxi Gao,Christopher J.Bakkenist,and jing Hu.HDAC2 promotes eIF4E sumolation and activates mRNA translation gene specifically. JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(24):18139-18143.(*Co-first author,IF:5.328)(中科院分区生物学2区;JCR生物化学Q1) (cited:31)
代表性授权发明专利:
(1) 徐祥;梁华平;王正国.核因子-kB p50亚基拮抗肽及其制备与应用,中国发明专利,专利号:200510069461.5(2006.12.27授权)。(第一发明人)
(2) 徐祥;梁华平;王正国.核因子-kB p65亚基拮抗肽及其应用,中国发明专利,专利号:200510007479.2(2007.3.14授权)。(第一发明人)
(3) 梁华平;徐祥;王正国.核因子-kB p50亚基结合肽及其制备与应用,中国发明专利,专利号:200510069428.2(2007年授权)。(第二发明人)
(4) 梁华平;徐祥;王正国.核因子-kB p65亚基结合肽及其制备与应用,中国发明专利,专利号:200510069451.1(2007年授权)。(第二发明人)
(5) 徐祥;袁洪峰;黄宏;郭韡;邢伟;梁华平.新型双功能抗瘢痕和组织纤维化药物,中国发明专利,专利号:201110001699.x(2013年1月2号授权)(第一发明人)
(6) 徐祥;郭韡;邢伟;黄宏;罗安雄;陈东风.抗瘢痕和组织纤维化寡聚双链核苷酸药物及其应用,中国发明专利,专利号:201310089302.6。(第一发明人,2015年7月22日授权)
(7) 敖罗权,徐祥,敖翔。靶向叶酸受体α嵌合抗原受体、其制备方法及其应用,中国发明专利,202111163687.7
(8) 徐祥,敖翔,敖罗权。一种基于假attP位点自发定向整合的通用型微环DNA表达载体及其构建方法与应用,中国发明专利,202110801525.5,授权日:2023.12.15。
(9) 周兴,徐祥,张成元,李子黎,袁玉川。一种高效低毒的自组装阳离子纳米粒及制备方法和应用,中国发明专利,202111181976.X
(10) 徐祥,夏雪伟,姚孟维,李战,闾开颜。CD83+、CD83+PD-L1+间充质干细胞及其制备方法和应用,中国发明专利,2023115505347,申请日:2023.11.21。
(11) 徐祥,夏雪伟,姚孟维,李战,闾开颜。CD83+、CD83+PD-L1+间充质干细胞及其制备方法和应用,国际(美日欧),PCT/CN2023/135087,申请日:2023.12.6。