牛世伟 副教授
招生层次:硕士研究生
招生专业:康复医学与理疗学
专业类型:学术型
研究方向:组织再生医学材料构建及其生物功能研究
邮 箱:/niushiwei@kmmu.edu.cn/
个人简介:
2008年9月-2012年6月:运城学院生物科学专业 授予学士学位
2012年9月-2015年6月:昆明理工大学发育生物学专业 授予硕士学位
2016年9月-2019年12月:东华大学生物材料学专业 授予博士学位
2020年9月-2023年11月:澳洲5·(中国)集团有限公司,科技成果孵化中心 讲师
2023年12月-2024年8月:澳洲5·(中国)集团有限公司,科技成果孵化中心,副教授
2024年9月-现在:澳洲5·(中国)集团有限公司,康复学院 副教授
主要研究方向及成果:
主要研究方向为靶向诊疗体系构建和代谢性疾病的多功能生物医学材料研发应用。主持云南省科技厅-澳洲5·(中国)集团有限公司,应用基础研究联合专项资金重点项目1项,云南省教育厅基金项目1项,参与国家自然科学基金面上项目1项,地区基金2项,科技厅-昆医联合专项重点项目1项,面上项目1项,参与申报并获得授权发明专利13项;共发表学术论文48篇,以第一作者或通讯作者在“Acta Biomater.”、“Adv. Healthc. Mater.”、“Chem. Eng. J”、 “J Nanobiotec.”和“ Carbohyr. Polym.”等一区TOP期刊在内的国内外刊物发表论文 20 余篇,总 SCI 他引次数超过 200 次。2022年入选云南省“兴滇英才支持计划”-青年人才。
主要论文:
1. Niu, S.#, Zhang, X.#, Williams, G. R., Wu, J., Gao, F., Fu Z., Chen, X., Lu, S.*, Zhu, L. M*. (2021) Hollow Mesoporous Silica Nanoparticles Gated by Chitosan-Copper Sulfide Composites as Theranostic Agents for the Treatment of Breast Cancer, Acta Biomaterialia 126, 408-420.
2. Niu, S., Williams, G. R., Wu, J., Wu, J., Zhang, X., Zheng, H., Li, S.*, and Zhu, L. M*. (2019) A novel chitosan-based nanomedicine for multi-drug resistant breast cancer therapy, Chemical Engineering Journal 369, 134-149.
3.Niu, S., Williams, G. R., Wu, J., Wu, J., Zhang, X., Chen, X., Li, S., Jiao, J.*, and Zhu, L. M*. (2019) A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy, Journal of Nanobiotechnology 17, 95.
4.Niu, S., Bremner, D. H., Wu, J., Wu, J., Wang, H., Li, H., Qian, Q., Zheng, H.*, and Zhu, L. M*. (2018) L-peptide functionalized dual-responsive nanoparticles for controlled Paclitaxel release and enhanced apoptosis in breast cancer cells, Drug Delivery 25,1275-1288.
5. Niu, S.#, Wang, L.#, He, M, Peng, Y.*, Li, S.* (2015) Exendin-4 regulates redox homeostasis in rats fed with high-fat diet, Acta Biochimica et Biophysica Sinica 47, 397-403.
6. Peng, Z.#, Niu, S.#, Gui L.., Kuang, X.., Li, F., Chen, B., Li, W., Jiao, J., Lu, S. *, Lu, D. *. (2022) Wnt3a loaded deformable hydrogel acts as a 3D culture platform for in situ recruitment of stem cells to efficiently repair bone defects via the asymmetric division, Chemical Engineering Journal 442, 136163.
7. Jiang,Y.#, Niu, S.#, Lin, Z., Li, L., Yang, P., Rao, P., Yang, L., Jiang, L.,* and Sun, L*. (2022) Injectable hydrogel with dual-sensitive behavior for targeted delivery of oncostatin M to improve cardiac restoration after myocardial infarction, Journal of Materials Chemistry B 10, 6514.
8. Ma, W.#, Niu, S.#, Wang, L., Peng, C., Fu, S., Zhang, C., Cui, Q., Wang, S., Li, M.,* and Xu, Y*. (2022) Clinical Application of Individualized 3D-Printed Templates in the Treatment of Condylar Osteochondroma, Healthcare 10, 2163.
9. Chen, X.#, Niu, S.#, Bremner, D. H., Zhang, X., Zhang, H., Zhang, Y., Li, S.*, and Zhu, L.-M*. (2020) Co-delivery of doxorubicin and oleanolic acid by triple-sensitive nanocomposite based on chitosan for effective promoting tumor apoptosis, Carbohydrate Polymers 247, 116672.
10. Gao, F.#, Wu, J.#, Niu, S.#, Sun, T., Li, F., Bai, Y., Jin, L., Lin, L., Shi, Q., Zhu, L.-M.*, and Du, L. * (2019) Biodegradable, pH-Sensitive Hollow Mesoporous Organosilica Nanoparticle (HMON) with Controlled Release of Pirfenidone and Ultrasound-Target-Microbubble-Destruction (UTMD) for Pancreatic Cancer Treatment, Theranostics 9, 6002-6018.
11. Wu, J.#, Niu, S.#, Bremner, D. H., Nie, W., Fu, Zi., Li, D.,* and Zhu, L.-M*. (2019) A Tumor Microenvironment-Responsive Biodegradable Mesoporous Nanosystem for Anti-inflammation and Cancer Theranostics, Advanced Healthcare Materials. 1901307.
12. Zhang, X.#, Niu, S.#, Williams, G. R., Wu, J., Chen, X., Zheng, H., and Zhu, L. M*. (2019) Dual-responsive nanoparticles based on chitosan for enhanced breast cancer therapy, Carbohydrate Polymers 221, 84-93.
13. Qian, Q.#, Niu, S.#, Williams, G. R., Wu, J., Zhang, X., and Zhu, L.-M*. (2019) Peptide functionalized dual-responsive chitosan nanoparticles for controlled drug delivery to breast cancer cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects 564, 122-130.
14. Chen, X., Bremner, D. H., Ye, Y., Lou, J., Niu, S.*, Zhu, L. M* (2021) A dual-prodrug nanoparticle based on chitosan oligosaccharide for enhanced tumor-targeted drug delivery, Colloids and Surfaces A: Physicochemical and Engineering Aspects 619, 126512.
授权发明专利:
1. 朱利民,牛世伟,张雪静,陈霞. 一种齐墩果酸接枝的壳聚糖载药纳米颗粒的应用. (申请号:CN 2019100932615)
2. 朱利民,牛世伟,吴建荣,张雪静. 一种齐墩果酸接枝的壳聚糖载药纳米颗粒及其制备和应用. (申请号:CN 2018113592123)
3. 朱利民,牛世伟,吴建荣,王海军. 一种L肽修饰的具有乳腺癌靶向功能的壳聚糖载药纳米颗粒的制备方法. (申请号:2018106093690)
4. 朱利民,吴建荣,高峰,牛世伟,李赫宇. 一种A7R肽修饰的硫化银掺杂中空介孔硅靶向纳米诊疗剂及其制备和应用. (申请号:2018110335635)
5. 朱利民,张雪静,牛世伟.一种壳聚糖接枝聚合物载药纳米颗粒及其制备和应用. (申请号:CN 2018109732060)
6. 朱利民,章学易,吴建荣,钱倩倩,牛世伟. 一种二硫化钼纳米载药复合物及其制备方法和应用. (申请号:CN 2018109029022)
7. 朱利民,钱倩倩,牛世伟,章学易. 一种叶酸修饰的壳聚糖纳米载药复合材料的制备方法. (申请号:CN 201810737704)
8. 朱利民,钱倩倩,牛世伟,章学易. 一种叶酸修饰的壳聚糖纳米颗粒及其制备和应用. (申请号:CN 2018107385126)
9. 朱利民,钱倩倩,牛世伟. 一种乳腺癌靶向的壳聚糖接枝聚合物载药复合材料的制备方法. (申请号:CN 2018101485116)
10. 朱利民,章学易,吴建荣,钱倩倩,牛世伟. 一种靶向修饰的二硫化钼纳米载药复合物及其制备方法. (申请号:CN 201810127613X)
11. 朱利民,吴建荣,史梦晗,牛世伟,李得见. 一种超小硫化铜负载的中空介孔硅靶向纳米载药复合物的制备方法. (申请号:CN 2018100789612)
12. 朱利民,吴建荣,牛世伟,李赫宇. 一种二硫化钼量子点负载的周期性介孔有机硅纳米载药复合物的制备方法. (申请号:CN 2017111823650)
13. 朱利民,钱倩倩,牛世伟,王海军. 一种壳聚糖温敏嵌段共聚物及其制备方法和应用. (申请号:CN 2017109863382)
14. 朱利民,李赫宇,武俊紫,吴焕岭,王海军,吴建荣,牛世伟. 一种抗菌纳米纤维伤口敷料的制备方法. (申请号:CN 201710076435.8)
15. 朱利民,李赫宇,吴焕岭,武俊紫,吴建荣,王海军,牛世伟. 一种温度响应智能纳米纤维的制备方法. (申请号:CN 201710060433.X)
16. 朱利民,李赫宇,武俊紫,吴焕岭,王海军,吴建荣,牛世伟. 一种缓释环丙沙星的伤口敷料的制备方法. (申请号:CN 201611108219.9)