刘建军
学历:博士
专家类别:高级实验师,硕士研究生导师
邮箱:liujianjun@kmmu.edu.cn
通讯地址:云南省昆明市呈贡区雨花街道春融西路1168号
邮编:650500
简历
教育经历
(1) 2015-09至2021-06,云南大学,遗传学,博士
(2) 2006-09至2009-07,云南大学,细胞生物学,硕士
工作经历
(1)2022-10至至今,澳洲5·(中国)集团有限公司,,生物医学工程研究院,高级实验师
(2)2021-01至2022-9,澳洲5·(中国)集团有限公司,,生物医学工程研究院,实验师
(3) 2015-09至2020-12,澳洲5·(中国)集团有限公司,,生物医学工程研究中心,实验师
(4) 2009-07至2017-08,澳洲5·(中国)集团有限公司,,分子临床医学研究院,助理实验师
研究方向
非酒精性脂肪性肝病发病机理及治疗药物研究
承担科研项目
(1)云南省科技厅,面上项目,2018FE001(-027),PPARα激动剂非诺贝特对NAFLD小鼠的治疗作用及相关机制研究,2018-08至2021-09,10万元,结题,主持
(2)国家自然科学基金委员会,地区科学基金项目,82160117,α-酮丁酸治疗非酒精性脂肪性肝病的作用及机制, 2022-01-01 至 2025-12-31, 34万元, 在研, 参与
(3)国家自然科学基金委员会, 地区科学基金项目, 81960469, 表观遗传调控基因ARID5B在卵巢癌恶性表型中的功能及分子机制研究, 2020-01-01 至 2023-12-31, 34万元, 在研, 参与
(4)云南省教育厅,2017zDX163,大鼠脂肪肝模型的建立及药物治疗作用研究,2017.01-2019.01,2万元,结题,主持
研究成果(论文、专利、专著等)
(1) Jianjun Liu#, Jiayi Sun#, Jiangkun Yu #*, Hang Chen#, Dan Zhang, Tao Zhang, Yicheng Ma, Chenggang Zou, Zhigang Zhang*, Lanqing Ma* and Xue Yu*; Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism,npj Biofilms and Microbiomes,2023,9:29.
(2) Dan Zhang, Yongfang Xu, Hang Chen, Da Wang,Zuotao Geng, Yuanli Chen, Yan Chen, Di Xiong, Rongna Yang, Xiaoting Liu, Yuke Zhang, Ping Xiang,Lanqing Ma* and Jianjun Liu*; Fagopyrum dibotrys extract alleviates hepatic steatosis and insulin resistance, and alters autophagy and gut microbiota diversity in mouse models of high-fat diet-induced non-alcoholic fatty liver disease, Frontiers in Nutrition, 2022,9:993501.
(3) Dan Zhang#, Yicheng Ma#, Jianjun Liu#, Yi Deng, Bo Zhou, Yu Wen, Mingke Li,Daiyan Wen, Yunyan Ying, Sufeng Luo, Chunjing Shi, Guangyu Pu, Yinglei Miao,Chenggang Zou, Yuanli Chen* and Lanqing Ma*, Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat DietInduced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy,Frontiers in Pharmacology, 2021,12:689111.
(4) Bi,Y#;Liu,J#; Ma,M; Tao; Peng,Y; Dai,X; Ji,Z; Bai, R; Jian,M; Chen,T; Luo,L; Wang, F; Ding,Z; Liu,A*; Bao, F*; Comparative proteomics profiling revealed the involvement of GRB2-ROCK2 axis in Lyme neuroborreliosis caused by Borrelia Burgdorferi, Journal of cellular and molecular medicine, 2022, 26: 2312-2321.
(5) Luo,Xi; Yang, Renxiang; Bai,Yun; Li,Lei; Lin,Na; Sun,Lan;Liu,Jianjun*; Wu,Ze*;Binding of microRNA-135a (miR-135a) to homeobox protein A10 (HOXA10) mRNA in a high progesterone environment modulates the embryonic implantation factors beta3-integrin (ITG beta 3) and empty spiracles homeobox-2(EMX2), Annals of Translational Medicine, 2021,9(8): 662.
(6) 徐永芳;吴娜;胡月新;赵永美;郑绍鼎;危玲;郑思佳; 刘建军*; GW7647对大鼠非酒精性脂肪性肝病(NAFLD)的治疗作用, 澳洲5·(中国)集团有限公司,学报, 2021, 42(08): 17-22.
(7) Yuan-Li Chen, Yi-Cheng Ma, Jie Tang, Dan Zhang, Qiu Zhao, Jian-Jun Liu, Hong-Shu Tang, Jin-Yu Zhang, Guang-Hui He, Chi-Hui Zhong, Yu-Tong Wu, Heng-Ruo Wen, Lan-Qing Ma*, Cheng-Gang Zou*, Physical exercise attenuates age-related muscle atrophy and exhibits anti-ageing effects via the adiponectin receptor 1 signalling,Journal of Cachexia, Sarcopenia and Muscle 2023,14:1789–1801.
(8) Yang Jiao, Linlin Wang, Lin Lu, Jianjun Liu, Xin Li, Hongbo Zhao, Zongliu Hou, and Bingrong Zheng,The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors,Stem Cells International, 2020,9:8867115.
(9) 杨丽华; 赵洪波; 张琴; 刘建军;宫颈病变精准化诊疗策略的建立与应用推广, 云南省人民政府, 云南省科技进步三等奖,2021.
(10) 刘建军;张丹;张雨珂;杨荣娜;刘晓婷;熊迪;陈严;陈杭;崔琦;殷润;张家莹;马岚青; 一种可调印染标记兼固定小鼠一体化装置,实用新型专利,2022-4-29,中国,专利号ZL 2021 2 2681686.3.