张龙龙
学历：博士
专家类别：副研究员，硕士研究生导师，云南省“兴滇英才支持计划”青年人才
邮箱：zhanglonglong@kmmu.edu.cn
通讯地址：云南省昆明市呈贡区雨花街道春融西路1168号
邮编：650500
简历
工作经历：
(1) 2023-03至今,澳洲5·（中国）集团有限公司,,生物医学工程研究院,副研究员
博士后经历：
(1) 2021-01至2023-03,云南大学，省部共建云南生物资源保护与利用国家重点实验室
教育经历：
(1) 2017-09至2021-01,中国科学院昆明动物研究所,细胞生物学,博士
(2) 2014-09至2017-07,云南大学,遗传学,硕士
(3) 2010-09至2014-07,河南农业大学,生物技术,学士
研究方向
主要从事抗乳腺癌化合物的活性研究、作用机理解析和药效评价，以及通过开发新的乳腺癌治疗靶点筛选小分子化合物，发现小分子或药物的新机制和新的联合用药策略。
承担科研项目
1. 靶向PI3Kα的PROTAC分子抑制乳腺癌的功能与机制研究，国家自然科学基金青年项目，2025.01-2027.12，30万，主持，在研。
2. 线粒体靶向化合物Arthrocolins A-C抗肿瘤机制研究，国家自然科学基金，2023.01-2026.12，33万，主持，在研。
3. 靶向泛素化降解KLF5的小分子化合物抑制三阴性乳腺癌的研究，云南省基础研究专项-面上项目，2024.03-2027.02，主持，在研。
4. 线粒体靶向化合物Arthrocolins A-C诱导卵巢癌细胞发生铁死亡的作用机制，云南省博士后研究项目，2021.12-2023.01，主持，结题。
研究成果（论文、专利、专著等）
发表论文（#表示共同第一作者；*表示通讯作者）
1. Hongyan Zhang#,Longlong Zhang#, Yuna He#, Dewei Jiang, Jian Sun, Qianmei Luo, Huichun Liang, Tiantian Wang, Fubing Li, Yu Tang, Zimo Yang, Wenjing Liu*, Yu Rao*, Ceshi Chen*.PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer.Cancer Letter. 2024.598: 217112. (中科院1区，IF：9.1)
2. Tiantian Wang#,Longlong Zhang#, Fubing Li#, Jie Zhang, Zhibi Zhang, Dazhao Mi, Jian Sun, Hongyan Zhang, Chunyan Wang*,Yihua Chen*, Ceshi Chen*. LN-439A, a Novel BAP1 Inhibitor, Suppresses the Growth of Basal-like Breast Cancer by Degrading KLF5.Acta Pharmacologica Sinica. 2024.(中科院1区，IF：7.6)
3. Zhuang Wu#, Qunfu Wu#, Wenli Yuan#, Yonghong Chen, Di Hu, Keqin Zhang, Deyao Deng*,Longlong Zhang*, Xuemei Niu*. Arthrocolins Synergizing with Fluconazole Inhibit Fluconazole-ResistantCandida albicans by Increasing Riboflavin Metabolism and Causing Mitochondrial Dysfunction and Autophagy.Microbiology Spectrum. 2023. 27: e0405122. (中科院1区，IF：9.04)
4. Qijun Zhou#, Xingyan Liu#,Longlong Zhang#, Rong Wang, Tingting Yin, Xiaolu Li, Guimei Li, Yuqi He, Zhaoli Ding, Pengcheng Ma, Shizhi Wang, Bingyu Mao*, Shihua Zhang*, Guodong Wang*. A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication,National Science Review, 2022. 9(11): nwac147. (中科院1区，IF-5年：23.92)
5. Xiaoyu Yang#, Yonghong Chen#,Longlong Zhang#, Jiangbo He#, Qunfu Wu, Shuhong Li, Jianghui Gou, Donglong Wang, Keqin Zhang, Shenghong Li*, Xuemei Niu*. Melanin Precursors Mediated Adaption to Temperature Changes in Fungus and Animal via Inhibition of Lipid-Mediated Ferroptosis,SCIENCE CHINA Life Sciences. 2023.66(8):1800-1817. (中科院1区，IF：10.384)
6. Longlong Zhang#, Yajun Liu #, Yonghong Chen, Zhuang Wu, Boran Liu, Qianyi Cheng, Keqin Zhang, Xuemei Niu*. Modulating activity evaluation of gut microbiota with versatile toluquinol.International Journal of Molecular Sciences. 2022. 23(18): 10700.
7. Longlong Zhang#, Maosen Ye#, Liang Zhu, Jingmei Cha, Chaocui Li, Yonggang Yao, Bingyu Mao*. Loss of ZC4H2 and RNF220 inhibits neural stem cell proliferation and promotes neuronal differentiation,Cells. 2020. 9(7): 1600.
8. Yonghong Chen#,Longlong Zhang#, Lijun Wang#, Xutong Yue, Qunfu Wu, Yang Jiang, Keqin Zhang, Xuemei Niu*. Acetylation of sesquiterpenyl epoxy-cyclohexenoids regulates fungal growth, stress resistance, endocytosis, and pathogenicity of nematode-trapping fungusArthrobotrys oligospora via metabolism and transcription.Journal of Agricultural and Food Chemistry. 2022. 70(20), 6145–6155. (中科院1区，IF-5年：6.04)
9. Xingwang Zhao#,Longlong Zhang#, Juan Wang, Min Zhang, Zhiqiang Song, Bing Ni*, Yi You*. Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis,Journal of Translational Medicine. 2021. 19(1): 64.
10. Qianqian Liu#, Longlong Zhang#, Yayan Zou, Ying Tao, Bing Wang, Bin Li, Ruai Liu, Boyong Wang, Lei Ding, Qinghua Cui, Jie Lin, Bingyu Mao, Wei Xiong*, Min Yu*. Modulating p-AMPK/mTOR pathway of mitochondrial dysfunction caused by MTERF1 abnormal expression in colorectal cancer cells.International Journal of Molecular Sciences. 2022. 23(20), 12354.
11. Ya Wen#, Qunfu Wu#,Longlong Zhang#, Jiangbo He#, Yonghong Chen, Xiaoyu Yang, Keqin Zhang, Xuemei Niu*, Shenghong Li*. Association of intrauterine microbes with endometrial factors in intrauterine adhesion formation and after medicine treatment.Pathogens. 2022. 11(7), 784.
12. Yonghong Chen#, Xiaoyu Yang#,Longlong Zhang#,Qunfu Wu#, Shuhong Li, Jianghui Gou, Jiangbo He, Keqin Zhang, Shenghong Li*,Xuemei Niu*. Tryptophan-centered metabolic alterations coincides with lipid-mediated fungal response to cold stress.Heliyon. 2023. 9(2): e13066.
专利：
(1) 张龙龙，茶靖美，王维丽；一种Venn富集分子筛及其应用，2023-06-07，中国，公开，CN202310666715.X.
(2) 陈策实，张龙龙，晏英，朱玉，彭明友；柠檬苦素类化合物在制备预防和/或治疗癌症药物中的应用，2024-07-23，中国，授权，CN118236368B.
(3) 陈策实，陈益华，张龙龙，汪田甜；一种去泛素化酶抑制剂在制备预防或者治疗炎症药物中的应用，2024-07-23，中国，授权，CN118161490B.
(4) 牛雪梅，张龙龙，陈永红，刘亚君，张克勤；一种化合物在预防和/或治疗癌症中的用途，2023.06.27，中国，授权，CN114306291B.
