法医学院博士研究生导师——陈勇彬



一、个人简介

陈勇彬,博士,研究员,博导,博士后合作导师。中国科学院昆明动物研究所PI。国家高层次人才特殊支持计划科技创新领军人才,科技部创新人才推进计划中青年科技领军人才,国家优青,国家海外高层次人才引进计划青年项目获得者,中国科学院海外高层次人才,云南省有突出贡献优秀专业技术人才,云南省高端科技人才,云南省海外高层次人才,云南省高层次人才培养支持计划产业技术领军人才,云岭学者项目支持。主持国家基金项目7项,中国科学院项目2项,省部级项目8项。作为唯一/共同通讯作者发表SCI论文50余篇,总IF大于530。参编著作3部。获云南省青年科技奖,云南省科学技术进步奖特等奖、一等奖、二等奖各1项,授权国家发明专利8项。

二、主要研究方向

1)法医病理生理学;(2)肿瘤新生物标志物挖掘及抗肿瘤新药筛选。

三、近五年主要承担科研项目

1)国家自然科学基金重点项目,82230099,GLT8D1抑制铁死亡促进肿瘤免疫逃逸的功能与机制研究,2023.01-2027.12,261万,在研,主持。

2)国家自然科学基金-云南联合基金,U2102206,GLT8D1通过CD133/Wnt/β-catenin轴影响胶质瘤干细胞活性和肿瘤进展的功能与机制研究,2022.01-2025.12,233万,在研,主持。

3)云南省基础研究计划-重大项目,202401BC070013,极端环境进化适应与实体瘤异质性形成的共性研究,2024.03-2027.02,300万,在研,主持。

4)“兴滇英才支持计划”云岭学者项目支持,肿瘤低氧微环境时空变化与肿瘤异质性,2024.01-2026.12,500万,在研,主持。

5)云南省重大科技专项计划生物医药专项,202202AA100007,治疗胶质瘤靶向药物乐卡地平临床前研究,2022.01-2024.12,300万,在研,主持。

6)国家自然科学基金面上项目,81772996,凝缩蛋白家族成员NCAPH影响结直肠癌发生发展的功能与机制研究,2018.01-2021.12,55万,结题,主持。

7)中国科学院科研仪器设备研制项目,YJKYYQ20190048,生物组织光层析大视场显微成像系统,2020.01-2021.12,300万,结题,主持。

8)云南省应用基础研究重点项目,202001AS070037,高原动物趋同进化适应候选基因的筛选及功能机制研究,2020.06-2023.05,50万,结题,主持。

四、近五年代表性学术成果

1)Qiushuo Shen#, Yanfei Han#, Kai Wu#, Yaomei He, Xiulin Jiang, Peishen Liu, Cuifeng Xia, Qiuxia Xiong,Rui liu, Qianming Chen, Yong Zhang, Song Zhao*, Cuiping Yang*,Yongbin Chen*.MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling .Signal Transduction and Targeted Therapy. 2022 May 4;7(1):147.(IF= 39.3)

2)Kun Liu#,Liping Jiang#, Yulin Shi,Baiyang Liu,Yaomei He, Qiushuo Shen,Xiulin Jiang,Zhi Nie,Jun Pu,Cuiping Yang,Yongbin Chen*.Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation.Cell Death and Differentiation.2022 Sep;29(9):1834-1849.(IF= 12.4)

3)Yaomei He#, Xiulin Jiang#, Lincan Duan#, Qiuxia Xiong, Yixiao Yuan, Peishen Liu, Liping Jiang, Qiushuo Shen, Song Zhao, Cuiping Yang*,Yongbin Chen*.LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.Molecular Cancer.2021 Dec 2;20(1):156(IF= 41.444)

4)Qiuxia Xiong#, Liping Jiang#, Kun Liu#, Xiulin Jiang, Baiyang Liu, Yulin Shi, Dating Cheng, Yong Duan*, Cuiping Yang*, Yongbin Chen *.miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer.Signal Transduction and Targeted Therapy.2021 Jul 7;6(1):252(IF= 38.12)

5)Xiulin Jiang#, Baiyang Liu#, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang?, Yongbin Chen?.The role of m6A modification in the biological functions and diseases.Signal Transduction and Targeted Therapy.2021 Feb 21;6(1):74(IF- 38.12)

6)Peifang Xu#, Liping Jiang#, Yang Yang#, Mengge Wu, Baiyang Liu, Yulin Shi, Qiushuo Shen, Xiulin Jiang, Yaomei He, Dating Cheng, Qiuxia Xiong, Zuozhang Yang, Lincan Duan, Jie Lin, Song Zhao, Peng Shi, Cuiping Yang*, Yongbin Chen*.PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.Theranostics.2020 Feb 19;10(8):3767-3778(IF= 11.556)

7)Yulin Shi#, Songqing Fan#, Mengge Wu#, Zhixiang Zuo,  Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu,  Lin Zeng, Yongchun Zhou, Yunchao Huang,  Zuozhang Yang,  Jumin Zhou,Jing Gao, Hu Zhou, Shuhua Xu,  Hongbin Ji, Peng Shi, Dongdong Wu*, Cuiping Yang*, Yongbin Chen*.YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.Nature Communications. 2019 Oct 25;10(1):4892.(IF= 12.121)

8)Xiulin Jiang#, Yong Zhang#, Yixiao Yuan#, Zhixian Jin#, Haoqing Zhai, Baiyang Liu, Yao Li, Chun Zhang, Min Chen, Yulin Shi, Dongming Yan*, Jun Pu*, Yongbin Chen*, Cuiping Yang*.LncRNA GSCAR promotes glioma stem cell maintenance via stabilizing SOX2 expression.International Journal of Biological Sciences. 2023 Mar 5;19(6):1681-1697(IF= 10.75)

9)Dongming Xu#, Cuiping Yang#, Qiushuo Shen#, Shengkai Pan#,Zhen Liu#, Tongzuo Zhang#, Xin Zhou, Menglong Lei, Peng Chen,Hui Yang, Tao Zhang,Yuanting Guo, Xiangjiang Zhan*, Yongbin Chen*,  Peng Shi*.A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau.Cell Research.2021 Sep;31(9):1032-1035(IF= 46.351)

10)Dongdong Wu*#, Cuiping Yang#, Mingshan Wang #, Kunzhe Dong #, Dawei Yan #, Ziqian Hao#, Songqing Fan, Shuzhou Chu, Qiushuo Shen, Liping Jiang , Yan Li , Lin Zeng, Hequn Liu, Haibing Xie, Yunfei Ma, Xiaoyan Kong , Shuli Yang , Xinxing Dong , Ali Esmailizadeh, David M Irwin, Xiao Xiao, Ming Li, Yang Dong, Wen Wang, Peng Shi, Haipeng Li, Yuehui Ma*, Xiao Gou*, Yongbin Chen*, Yaping Zhang*.Convergent genomic signatures of high-altitude adaptation among domestic mammals.National Science Review. 2020 Jun;7(6):952-963(IF= 17.275)

五、联系邮箱: ybchen@mail.kiz.ac.cn






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