一、个人简介:
李利华,男,二级教授,博士生导师,博士后合作导师。澳洲5·(中国)集团有限公司,党委常委、副校长,国家卫生健康委毒品依赖和戒治重点实验室主任。享受国务院政府特殊津贴,教育部高等学校法医学类专业教学指导委员会委员,云南省中青年学术和技术带头人,云南省委联系专家,司法部司法鉴定能力验证技术专家。现担任全国高等法医学教育研究会常务理事、云南省高等教育学会副会长、澳洲5·(中国)集团有限公司,校友会副理事长。获中华人民共和国司法部法律服务工作者先进个人、全国司法鉴定先进个人等荣誉称号。
从事高校法医学教育、科研和司法鉴定工作35年。主要研究领域为毒品成瘾与戒断干预技术、法医病理学和毒理学损伤机制研究,在国内法医学和禁毒研究领域有较大学术影响力和知名度。主持承担国家自然科学基金项目5项,主持承担省科技计划项目9项,参与国家和省级科技计划项目11项。以第一作者或通讯作者发表学术论文100多篇,SCI收录24篇。主编、副主编和参编国家级规划教材、专著15部。获云南省科技进步三等奖5项,获云南省教学成果一等奖1项、二等奖2项。
二、主要研究方向:
毒品成瘾与戒断干预技术、法医病理学和毒理学损伤机制研究。
三、近五年主要承担科研项目:
1.国家自然科学基金面上项目,《TRPV1对甲基苯丙胺依赖记忆印迹的调控机制及大麻二酚的干预作用》(2024.01-2027.12),主持。
2.国家自然科学基金地区项目,《甲基苯丙胺成瘾者脑功能磁共振检测和神经毒性损害机制》(2019.01-2022.12),主持。
四、近五年代表性学术成果:
1.Wenjuan Dong#, Jia Wan# , Hao Yu , Baoyu Shen , Genmeng Yang , Qianyun Nie , Yan Tian , Lixiang Qin, Chunhui Song , Bingzheng Chen, Lihua Li,* Shijun Hong.* Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice[J].Toxicology Letters, 384 (2023) 136-148
2. Baoyu Shen; Dongxian Zhang; Xiaofeng Zeng; Lina Guan; Genmeng Yang; Liu Liu; Jian Huang;Yuanyuan Li; Shijun Hong*; Lihua Li* ; Cannabidiol inhibits methamphetamine-induced dopamine release via modulation of the DRD1-MeCP2-BDNF-TrkB signaling pathway, Psychopharmacology, 2022, 239(5):1521-15372.
3.Baoyu Shen; Ruilin Zhang; Genmeng Yang; Yanxia Peng; Qianyun Nie; Hao Yu; Wenjuan Dong;Bingzheng Chen; Chunhui Song; Yan Tian; Lixiang Qin; Junjie Shu; Shijun Hong*; Lihua Li*;Cannabidiol prevents methamphetamine-induced neurotoxicity by modulating dopamine receptor D1-mediated calcium-dependent phosphorylation of methyl-CpG-binding protein 2, Frontiers in Pharmacology, 2022, 13: 972828.
4.Genmeng Yang; Juan Li; Chi-Kwan Leung; Baoyu Shen; Chan Wang; Yue Xu; Shucheng Lin;Shuwei Zhang; Yi Tan; Huijie Zhang; Xiaofeng Zeng*; Shijun Hong*; Lihua Li *; Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway, Neuropharmacology, 2022, 220: 109256
5.Hao Yu; Yanxia Peng; Wenjuan Dong; Baoyu Shen; Genmeng Yang; Qianyun Nie; Yan Tian;Lixiang Qin; Chunhui Song; Bingzheng Chen; Yongna Zhao; Lihua Li*; Shijun Hong* ; Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice, Human Experimental Toxicology, 2023, 42: 1-11
6. Qianyun Nie; Wenjuan Dong; Baoyu Shen; Genmeng Yang; Hao Yu; Ruilin Zhang; Yanxia Peng;Yang Yu; Shijun Hong*; Lihua Li* ; Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats, Annals of Translational Medicine, 2022, 1(18): 985-985
7.Gen-Meng Yang#; Lu Li#; Feng-Lin Xue; Chen-Li Ma; Xiao-Feng Zeng; Yong-Na Zhao; Shi-Jun Hong*; Li-Hua Li*; The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line, Neurotoxicity Research, 2020, 37: 926-935.
8.C-L Ma#; L Li#; G-M Yang; Z-B Zhang; Y-N Zhao; X-F Zeng; D-X Zhang; Y Yu; Z-J Shi; Q-W Yan; L-H Li*; S-J Hong*; Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron, Human and Experimental Toxicology, 2020, 39(8): 1118–1129.
五、联系邮箱:lilihua1229@126.com